Tuesday, March 5, 2013

Hugo Chavez, fiery Venezuelan leader, dies at 58

FILE - In this July 21, 2006 file photo, Venezuela's President Hugo Chavez, left, gestures as Cuba's President Fidel Castro looks on during an event in Cordoba, Argentina. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died at age 58 after a nearly two-year bout with cancer. (AP Photo/Roberto Candia, File)

FILE - In this July 21, 2006 file photo, Venezuela's President Hugo Chavez, left, gestures as Cuba's President Fidel Castro looks on during an event in Cordoba, Argentina. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died at age 58 after a nearly two-year bout with cancer. (AP Photo/Roberto Candia, File)

FILE - In this Jan. 23, 2002 file photo, Venezuela's President Hugo Chavez waves to supporters during a government march commemorating the anniversary of Venezuelan democracy in Caracas, Venezuela. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died. Chavez, 58, was first diagnosed with cancer in June 2011. (AP Photo/Fernando Llano, File)

FILE - In this Nov. 19, 2005 file photo, Venezuela's President Hugo Chavez wears a Mexican sombrero as he sings a Mexican ranchera song at a rally in Caracas, Venezuela. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died. Chavez, 58, was first diagnosed with cancer in June 2011. (AP Photo/Fernando Llano, File)

In this July 5, 1975 photo released by Miraflores Press Office, Hugo Chavez, center, poses with his mother Elena Frias and father Hugo de los Reyes Chavez at his graduation from the military academy in Caracas, Venezuela. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died. Chavez, 58, was first diagnosed with cancer in June 2011. (AP Photo/Miraflores Press Office)

FILE - In this March 31, 2011 file photo, Venezuela's President Hugo Chavez, right, and Bolivia's President Evo Morales, dressed in traditional Quechua indigenous clothing, wave to supporters at a welcoming ceremony for Chavez in Cochabamba, Bolivia. Venezuela's Vice President Nicolas Maduro announced on Tuesday, March 5, 2013 that Chavez has died. Chavez, 58, was first diagnosed with cancer in June 2011. (AP Photo/Juan Karita, File)

CARACAS, Venezuela (AP) ? President Hugo Chavez was a former paratroop commander and self-styled "subversive" who waged continual battle for his socialist ideals. He bedeviled the United States and outsmarted his rivals time and again, while using Venezuela's vast oil wealth to his political advantage.

Chavez led one coup attempt, defeated another and was re-elected three times. Almost the only adversary it seemed he couldn't beat was cancer. He died Tuesday in Caracas at age 58, two years after he was first diagnosed.

The son of schoolteachers, he rose from poverty in a dirt-floor, mud-walled house, a "humble soldier" in the battle for socialism. He fashioned himself after 19th-century independence leader Simon Bolivar and renamed his country the Bolivarian Republic of Venezuela.

During more than 14 years in office, his leftist politics and grandiose style polarized Venezuelans. The barrel-chested leader electrified crowds with his booming voice, and won admiration among the poor with government social programs and a folksy, nationalistic style.

Opponents seethed at the larger-than-life character who demonized them on television and ordered the expropriation of farms and businesses. Many in the middle class cringed at his bombast and complained about rising crime, soaring inflation and government economic controls.

Chavez used his country's oil wealth to launch social programs that included state-run food markets, new public housing, free health clinics and education programs. While poverty declined during his presidency amid a historic boom in oil earnings, critics said he failed to use the windfall of hundreds of billions of dollars to develop the country's economy.

Inflation soared and the homicide rate rose to among the highest in the world

Before his struggle with cancer, the charismatic leader appeared on television almost daily, speaking for hours and breaking into song or philosophical discourse. He often wore the bright red of his United Socialist Party of Venezuela, or the fatigues and red beret of his army days ? the same uniform he donned in 1992 while leading an ill-fated coup attempt that first landed him in jail and then launched his political career.

The rest of the world watched as the country with the world's biggest proven oil reserves took a turn to the left under its unconventional leader, who considered himself above all else a revolutionary.

"I'm still a subversive," Chavez told The Associated Press in a 2007 interview, recalling his days as a rebel soldier. "I think the entire world has to be subverted."

Chavez was a master communicator and savvy political strategist, and managed to turn his struggle against cancer into a rallying cry, until the illness finally defeated him.

From the start, he billed himself as the heir of Bolivar, who led much of South America to independence, often speaking beneath the 19th-century liberator's portrait and presenting replicas of his sword to allies. He built a soaring mausoleum in Caracas to house the remains of "El Libertador."

Chavez also was inspired by his mentor Fidel Castro and took on the Cuban leader's role as Washington's chief antagonist in the Western Hemisphere after the ailing Castro turned over the presidency to his brother Raul in 2006. Like Castro, Chavez decried U.S.-style capitalism while forming alliances throughout Latin America and with distant powers such as Russia, China and Iran.

Supporters eagerly raised Chavez to the pantheon of revolutionary legends ranging from Castro to Argentine-born rebel Ernesto "Che" Guevara. Chavez nurtured that cult of personality, and even as he stayed out of sight for long stretches during his bout with cancer, his out-sized image appeared on buildings and billboard throughout Venezuela. The airwaves boomed with his baritone mantra: "I am a nation." Supporters carried posters and wore masks of his eyes, chanting, "I am Chavez."

In the battles Chavez waged at home and abroad, he captivated his base by championing Venezuela's poor.

"This is the path: the hard, long path, filled with doubts, filled with errors, filled with bitterness, but this is the path," Chavez told his backers in 2011. "The path is this: socialism."

On television, he would lambast his opponents as "oligarchs," scold his aides, tell jokes, reminisce about his childhood, lecture Venezuelans on socialism and make sudden announcements, such as expelling the U.S. ambassador or ordering tanks to Venezuela's border with Colombia.

Chavez carried his in-your-face style to the world stage as well. In a 2006 speech to the U.N. General Assembly, he called President George W. Bush the devil, saying the podium reeked of sulfur after the U.S. president's address.

At a summit in 2007, he repeatedly called Spanish Prime Minister Jose Maria Aznar a fascist, prompting Spain's King Juan Carlos to snap, "Why don't you shut up?"

Critics saw Chavez as a typical Latin American caudillo, a strongman who ruled through force of personality and showed disdain for democratic rules. Chavez concentrated power in his hands with allies who dominated the congress and justices who controlled the Supreme Court.

"El Comandante," as he was known, insisted Venezuela remained a vibrant democracy and denied charges that he sought to restrict free speech. But some opponents faced criminal charges and were driven into exile. His government forced the opposition-aligned television channel, RCTV, off the air by refusing to renew its license.

While Chavez trumpeted plans for communes and an egalitarian society, his rhetoric regularly conflicted with reality. Despite government seizures of companies and farmland, the balance between Venezuela's public and private sectors changed little during his presidency.

Nonetheless, Chavez maintained a core of supporters who stayed loyal to their "comandante" until the end.

"Chavez masterfully exploits the disenchantment of people who feel excluded ... and he feeds on controversy whenever he can," Cristina Marcano and Alberto Barrera Tyszka wrote in their book "Hugo Chavez: The Definitive Biography of Venezuela's Controversial President."

Hugo Rafael Chavez Frias was born on July 28, 1954, in the rural town of Sabaneta in Venezuela's western plains, the son of schoolteachers and the second of six brothers. He was raised by his grandmother, Rosa Ines, in a home with a dirt floor, mud walls and a roof made of palm fronds.

Chavez was a fine baseball player and hoped he might one day pitch in the U.S. major leagues. When he joined the military at age 17, he aimed to keep honing his baseball skills in the capital.

But between his army duties and drills, the young soldier immersed himself in the history of Bolivar and other Venezuelan heroes who had overthrown Spanish rule, and his political ideas began to take shape.

Chavez burst into public view in 1992 as a paratroop commander leading a military rebellion that brought tanks to the presidential palace. When the coup collapsed, Chavez was allowed to make a televised statement in which he declared that his movement had failed "for now." The speech, and those two defiant words, launched his career, searing his image into the memory of Venezuelans.

Two years later, he and other coup leaders were released from prison, and President Rafael Caldera dropped the charges against them.

After organizing a new party, Chavez ran for president in 1998, pledging to clean up Venezuela's entrenched corruption and shatter its traditional two-party system. At age 44, he became the country's youngest president, winning 56 percent of the vote.

After he took office on Feb. 2, 1999, Chavez called for a new constitution, and an assembly filled with his allies drafted the document. Among various changes, it lengthened presidential terms from five years to six and changed the country's name to the Bolivarian Republic of Venezuela.

By 2000, his increasingly confrontational style and close ties to Cuba disenchanted many of the middle-class supporters who voted for him, and the next several years saw bold attempts by opponents to dislodge him from power.

In 2002, he survived a short-lived coup, which began after large anti-Chavez street protests ended in shootings and bloodshed. Dissident military officers detained the president and announced he had resigned. But within two days, he returned to power with the help of military loyalists amid massive protests by his supporters.

Chavez emerged a stronger president.

He defeated an opposition-led strike that paralyzed the country's oil industry and fired thousands of state oil company employees.

The coup also turned Chavez more decidedly against the U.S. government, which had swiftly recognized the provisional leader who briefly replaced him. He created political and trade alliances that excluded the U.S., and he cozied up to Iran and Syria in large part, it seemed, due to their shared antagonism toward the U.S. government. Despite the souring relationship, Chavez kept selling the bulk of Venezuela's oil to the United States.

By 2005, Chavez was espousing a new, vaguely defined "21st-century socialism." Yet the agenda didn't involve a sudden overhaul to the country's economic order, and some businesspeople continued to prosper. Those with lucrative ties to the government came to be known as the "Bolivarian bourgeoisie."

After easily winning re-election in 2006, Chavez began calling for a "multi-polar world" free of U.S. domination, part of an expanded international agenda. He boosted oil shipments to China, set up joint factories with Iran to produce tractors and cars, and sealed arms deals with Russia for assault rifles, helicopters and fighter jets. He focused on building alliances throughout Latin America and injected new energy into the region's left. Allies were elected in Bolivia, Ecuador, Argentina and other countries.

Chavez also cemented relationships with island countries in the Caribbean by selling them oil on preferential terms while severing ties with Israel, supporting the Palestinian cause and backing Iran's right to a nuclear energy program.

All the while, Chavez emphasized that it was necessary to prepare for any potential conflict with the "empire," his term for the United States.

He told the AP in 2007 that he loved the movie "Gladiator."

"It's confronting the empire, and confronting evil. ... And you end up relating to that gladiator," Chavez said as he drove across Venezuela's southern plains.

He said he felt a deep connection to those plains where he grew up, and that when died he hoped to be buried in the savanna.

"A man from the plains, from these great open spaces ... tends to be a nomad, tends not to see barriers. What you see is the horizon," Chavez said.

Running a revolution ultimately left little time for a personal life. His second marriage, to journalist Marisabel Rodriguez, deteriorated in the early years of his presidency, and they divorced in 2004. In addition to their one daughter, Rosines, Chavez had three children from his first marriage, which ended before he ran for office. His daughters Maria and Rosa often appeared at his side at official events and during his trips. He had one son, Hugo Rafael Chavez.

After he was diagnosed with cancer in June 2011, he acknowledged that he had recklessly neglected his health. He had taken to staying up late and drinking as many as 40 cups of coffee a day. He regularly summoned his Cabinet ministers to the presidential palace late at night.

Even as he appeared with head shaved while undergoing chemotherapy, he never revealed the exact location of tumors that were removed from his pelvic region, or the exact type of cancer.

Chavez exerted himself for one final election campaign in 2012 after saying tests showed he was cancer-free, and defeated younger challenger Henrique Capriles. With another six-year term in hand, he promised to keep pressing for revolutionary changes.

But two months later, he went to Cuba for a fourth cancer-related surgery, blowing a kiss to his country as he boarded the plane.

After a 10-week absence, the government announced that Chavez had returned to Venezuela and was being treated at a military hospital in Caracas. He was never seen again in public.

On Tuesday, Cuban folk singer Silvio Rodriguez posted photos on his blog of a past encounter with Chavez, the Venezuelan leader singing along as he strummed a guitar.

"Goodbye forever, comandante," Rodriguez wrote.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-05-Venezuela-Obit-Chavez/id-c5cb6f8267c141d3b00c70839a09e77f

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Jane C. Wright, Pioneering Oncologist, Dies at 93

[unable to retrieve full-text content]Dr. Wright defied racial barriers in a profession long dominated by white men and helped found the American Society of Clinical Oncology.

Source: http://www.nytimes.com/2013/03/03/health/jane-c-wright-pioneering-oncologist-dies-at-93.html?partner=rss&emc=rss

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Monday, March 4, 2013

One law to rule them all: Sizes within a species appear to follow a universal distribution

Mar. 4, 2013 ? Swiss Researchers at Eawag and EPFL discovered what might be a universal property of size distributions in living systems. If valid throughout the animal kingdom, it could have profound implications on how we understand population dynamics of large ecosystems.

Flocks of birds, schools of fish, and groups of any other living organisms might have a mathematical function in common. Studying aquatic microorganisms, Andrea Giometto, a researcher EPFL and Eawag, showed that for each species he studied, body sizes were distributed according to the same mathematical expression, where the only unknown is the average size of the species in an ecosystem. His article was published in PNAS in March 2013.

Several observations suggest that the size distribution function could be universal. Giometto made his observations in the lab on 14 species of aquatic microorganisms, including unicellular and multicellular ones that are very distant from an evolutionary point of view. The microorganisms he studied varied by four orders of magnitude, the difference in size between a mouse and an elephant.

Furthermore, the mathematical function describing the size distribution remained unchanged even when the species adapted to new environments -- changes in water temperature, the presence or absence of competitors -- by changing their average size. Based on these observations, Giometto and his collaborators suggest that two separate factors work in tandem to shape the size distribution of a species. First, environmental factors influence the average size of a species. Second, physiological factors, or genetics, cause the observed variability of species sizes around the average size.

From species to communities

So far the focus has been on the size distribution of individuals of a single species. But Giometto's findings become particularly interesting in light of an observation that is well known to ecologists. "If you take a cup of water from the sea and analyze all of the microorganisms it contains, you find that in an ecological community no size tends to be over or underrepresented," says Florian Altermann, the ecologist in the team. Mathematically, the sizes can be described by a power-law distribution.

Taken together, these observations of size distributions within a species and within all the species in a given ecological community have interesting implications. If in an ecosystem several species begin to converge around the same size, a balancing force will kick in to restore the power-law distribution, either by acting on the abundance or size of each species.

If, as Giometto and his co-authors speculate, their observations are valid beyond the species they studied, they may provide additional evidence for the existence of universal laws that govern natural ecosystems. These laws would regulate not only the size and abundance of organisms in an ecosystem, but also other properties, such as the number of species that co-exist.

Finding power-laws and using them to describe complex systems already has a successful track record. "In physics, the observation that systems followed power-laws was instrumental in understanding phase transitions. We believe that power-laws can be similarly helpful to gain a deeper understanding of how systems of living matter work," says Giometto, a physicist, who is seeking to apply methods from his field to understand biological ecosystems.

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The above story is reprinted from materials provided by EAWAG: Swiss Federal Institute of Aquatic Science and Technology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Andrea Giometto, Florian Altermatt, Francesco Carrara, Amos Maritan, Andrea Rinaldo. Scaling body size fluctuations. PNAS, March 2013 DOI: 10.1073/pnas.1301552110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/kowcg6170lk/130304151652.htm

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Maternal diet important predictor of severity for infant respiratory syncytial virus (RSV)

Mar. 4, 2013 ? An important predictor of the severity of respiratory syncytial virus (RSV) in infants may be what their mothers ate during pregnancy, according to a Vanderbilt study published in the American Journal of Respiratory and Critical Care Medicine.

RSV is the most common cause of severe lower respiratory tract disease among infants and young children worldwide. Currently there is no effective vaccine against RSV. Outbreaks occur in communities each year, usually lasting 4-5 months during the fall, winter and/or spring months.

Lead author Fernando Polack, M.D., Cesar Milstein Professor of Pediatrics, said his study found that the most serious cases of RSV correlate with mothers who ate a diet high in carbohydrates during pregnancy.

"These cases were not just severe, but the sickest of sick," Polack said. "What we found was the presumptive impact of a carbohydrate-rich diet was clearly dose dependent."

More than 1,200 infants younger than 2 years old were hospitalized in 12 institutions in Buenos Aires, Argentina, during the 2011 RSV season.

Of those patients, nearly 800 were found to have RSV infection, and 106 of those babies were considered to have a life-threatening form of the disease, with oxygen saturation rates below 87 percent: Twenty-two infants died in the hospital, and an additional 26 infants died at home with evidence suggesting they died from RSV.

Polack and his collaborators had the mothers fill out a nutrition survey during their final trimester of pregnancy in order to examine the impact of maternal diets heavy in fruits and vegetables versus protein, fats or carbohydrate-rich diets.

Overall, the frequency of life-threatening or fatal RSV in infants was about 12.7 percent among participants, but that rate jumped to 55.6 percent for babies whose mothers ate the greatest proportion of carbohydrates.

"Our study suggests that, where RSV and other respiratory viruses are concerned, the more sugars a mother eats the worse the situation may get for the baby in the first part of life," said Polack, adding that the next step will be to confirm the association in future studies.

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Story Source:

The above story is reprinted from materials provided by Vanderbilt University Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. F. M. Ferolla, D. R. Hijano, P. L. Acosta, A. Rodriguez, K. Duenas, A. Sancilio, E. Barboza, A. Caria, G. Fernandez Gago, R. Egues Almeida, L. Castro, C. Pozzolo, M. V. Martinez, L. Alva Grimaldi, B. Rebec, M. Calvo, J. Henrichsen, C. Nocito, M. Gonzalez, G. Barbero, J. Ves Losada, M. T. Caballero, V. Zurankovas, M. Raggio, G. Schavlovsky, A. Kobylarz, V. Wimmenauer, J. Bugna, J. V. Williams, G. Sastre, E. Flamenco, A. Rodriguez Perez, F. Ferrero, R. Libster, C. G. Grijalva, F. P. Polack. Macronutrients during Pregnancy and Life-Threatening Respiratory Syncytial Virus Infections in Children. American Journal of Respiratory and Critical Care Medicine, 2013; DOI: 10.1164/rccm.201301-0016OC

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/KjTHJr3Hu1A/130304105648.htm

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'Shelf life' of blood? Shorter than we think

'Shelf life' of blood? Shorter than we think [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

A small study from Johns Hopkins adds to the growing body of evidence that red blood cells stored longer than three weeks begin to lose the capacity to deliver oxygen-rich cells where they may be most needed.

In a report published online in the journal Anesthesia & Analgesia, the Johns Hopkins investigators say red cells in blood stored that long gradually lose the flexibility required to squeeze through the body's smallest capillaries to deliver oxygen to tissue. Moreover, they say, that capacity is not regained after transfusion into patients during or after surgery.

"There's more and more information telling us that the shelf life of blood may not be six weeks, which is what the blood banks consider standard," says study leader Steven M. Frank, M.D., an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. "If I were having surgery tomorrow, I'd want the freshest blood they could find."

Frank acknowledges that blood banks do not have enough fresh blood for everybody, and that shorter storage periods would result in diminished inventory. But he says that the current practice of transfusing blood stored up to six weeks may need to be reconsidered.

One previous, large study published in the New England Journal of Medicine has already shown that cardiac surgery patients who received blood stored longer than three weeks were almost twice as likely to die as patients who got blood that had been stored for just 10 days.

For the new study, Frank and his colleagues enrolled 16 patients scheduled to have spinal fusion surgery, a type of operation that typically requires blood transfusions. Six of the patients received five or more units of blood, while 10 needed three or fewer units. The researchers drew samples from every bag of blood used 53 in total and measured the flexibility of the red blood cells. What they found is that blood older than 3 weeks was more likely to have less flexible red blood cell membranes, a condition that may make it more difficult for blood to deliver oxygen, Frank says.

The team also took blood samples from patients in the three days following surgery. Even though the blood cells were out of storage and back in biological environments with proper pH (acidity), electrolytes and oxygen levels, the injury to the red cells was not reversible and appeared to be permanent. The damaged blood cells would likely remain dysfunctional for their life cycle limit, which is up to 120 days, Frank says.

Frank also noted that patients in the study who got fewer units of blood had healthier red cells overall, even though the blood was just as old and showed cell damage. He says it is likely that a small amount of these problem cells make less of a difference than when a large number of damaged cells are present.

According to the research report, the average age of the blood given in the study was more than 3 weeks. Only three samples in the study were 2 weeks old or less. One reason for the lack of availability of fresher bloods for adults, Frank says, is the routine practice of giving pediatric patients priority for the freshest units.

In fact, he notes, blood banks dispense the oldest blood first so that it doesn't exceed its shelf life before it can be used. "As a colleague said, it's like how they sell milk in the grocery store they put the oldest cartons out front so they can sell them before they expire," Frank says.

Two large randomized controlled studies, one at many centers across the United States, including Johns Hopkins, and one in Canada, are under way to determine the relative safety of older versus newer blood, and the results are expected next year. Frank says blood banks need to be prepared to change practice if those studies show that a six-week shelf life for blood is just too long.

###

The study was supported in part by the National Institutes of Health's National Institute on Aging (R01 AG021523) and National Heart, Lung, and Blood Institute (R01 HL092259-01).

Other Johns Hopkins researchers involved in the study include Bagrat Abazyan, M.D.; Masahiro Ono, M.D.; Charles W. Hogue, M.D.; David B. Cohen, M.D., M.P.H.; Daniel E. Berkowitz, M.D.; Paul M. Ness, M.D.; and Viachaslau M. Barodka, M.D.

Ness has consulted for Terumo BCT and Fenwal Labs, both companies involved with blood storage. Nothing in this study directly benefits these companies. The terms of these arrangements are being managed by The Johns Hopkins University in accordance with its conflict of interest policies.

For more information:

http://www.hopkinsmedicine.org/anesthesiology/faculty/bios/frank.shtml

http://www.hopkinsmedicine.org/news/media/releases/blood_transfusions_still_overused_and_may_do_more_harm_than_good_in_some_patients


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


'Shelf life' of blood? Shorter than we think [ Back to EurekAlert! ] Public release date: 4-Mar-2013
[ | E-mail | Share Share ]

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

A small study from Johns Hopkins adds to the growing body of evidence that red blood cells stored longer than three weeks begin to lose the capacity to deliver oxygen-rich cells where they may be most needed.

In a report published online in the journal Anesthesia & Analgesia, the Johns Hopkins investigators say red cells in blood stored that long gradually lose the flexibility required to squeeze through the body's smallest capillaries to deliver oxygen to tissue. Moreover, they say, that capacity is not regained after transfusion into patients during or after surgery.

"There's more and more information telling us that the shelf life of blood may not be six weeks, which is what the blood banks consider standard," says study leader Steven M. Frank, M.D., an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. "If I were having surgery tomorrow, I'd want the freshest blood they could find."

Frank acknowledges that blood banks do not have enough fresh blood for everybody, and that shorter storage periods would result in diminished inventory. But he says that the current practice of transfusing blood stored up to six weeks may need to be reconsidered.

One previous, large study published in the New England Journal of Medicine has already shown that cardiac surgery patients who received blood stored longer than three weeks were almost twice as likely to die as patients who got blood that had been stored for just 10 days.

For the new study, Frank and his colleagues enrolled 16 patients scheduled to have spinal fusion surgery, a type of operation that typically requires blood transfusions. Six of the patients received five or more units of blood, while 10 needed three or fewer units. The researchers drew samples from every bag of blood used 53 in total and measured the flexibility of the red blood cells. What they found is that blood older than 3 weeks was more likely to have less flexible red blood cell membranes, a condition that may make it more difficult for blood to deliver oxygen, Frank says.

The team also took blood samples from patients in the three days following surgery. Even though the blood cells were out of storage and back in biological environments with proper pH (acidity), electrolytes and oxygen levels, the injury to the red cells was not reversible and appeared to be permanent. The damaged blood cells would likely remain dysfunctional for their life cycle limit, which is up to 120 days, Frank says.

Frank also noted that patients in the study who got fewer units of blood had healthier red cells overall, even though the blood was just as old and showed cell damage. He says it is likely that a small amount of these problem cells make less of a difference than when a large number of damaged cells are present.

According to the research report, the average age of the blood given in the study was more than 3 weeks. Only three samples in the study were 2 weeks old or less. One reason for the lack of availability of fresher bloods for adults, Frank says, is the routine practice of giving pediatric patients priority for the freshest units.

In fact, he notes, blood banks dispense the oldest blood first so that it doesn't exceed its shelf life before it can be used. "As a colleague said, it's like how they sell milk in the grocery store they put the oldest cartons out front so they can sell them before they expire," Frank says.

Two large randomized controlled studies, one at many centers across the United States, including Johns Hopkins, and one in Canada, are under way to determine the relative safety of older versus newer blood, and the results are expected next year. Frank says blood banks need to be prepared to change practice if those studies show that a six-week shelf life for blood is just too long.

###

The study was supported in part by the National Institutes of Health's National Institute on Aging (R01 AG021523) and National Heart, Lung, and Blood Institute (R01 HL092259-01).

Other Johns Hopkins researchers involved in the study include Bagrat Abazyan, M.D.; Masahiro Ono, M.D.; Charles W. Hogue, M.D.; David B. Cohen, M.D., M.P.H.; Daniel E. Berkowitz, M.D.; Paul M. Ness, M.D.; and Viachaslau M. Barodka, M.D.

Ness has consulted for Terumo BCT and Fenwal Labs, both companies involved with blood storage. Nothing in this study directly benefits these companies. The terms of these arrangements are being managed by The Johns Hopkins University in accordance with its conflict of interest policies.

For more information:

http://www.hopkinsmedicine.org/anesthesiology/faculty/bios/frank.shtml

http://www.hopkinsmedicine.org/news/media/releases/blood_transfusions_still_overused_and_may_do_more_harm_than_good_in_some_patients


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/jhm-lo030113.php

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Drew Schnell - Psychology Today

[unable to retrieve full-text content]... depression/anxiety, mood disorders, psychosis, childhood trauma, transition age youth, grief and loss, couples' issues, sleep health, nutrition/weight loss, exercise/physical fitness. I am skilled in various mind-body therapies ...

Source: http://therapists.psychologytoday.com/rms/142993

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Romney: Heart told him he'd win, until he saw Fla.

(AP) ? Mitt Romney says his heart said he was going to win the presidency, but when early results came in on election night, he knew it was not to be.

The GOP nominee tells "Fox News Sunday" that he knew his campaign was in trouble when exit polls suggested a close race in Florida. Romney thought he'd win the state solidly.

Obama ended up taking Florida and won the election by a wide margin in the electoral vote.

Romney says there was "a slow recognition" at that time that President Barack Obama would win ? and the race soon was over when Obama carried Ohio.

Romney says the loss hit hard and was emotional. Ann Romney says she cried.

The former Massachusetts governor acknowledges mistakes in the campaign and flaws in his candidacy.

But he jokes that he did better in his second run for the White House than he did the first time around ? when he lost the 2008 nomination to Arizona Sen. John McCain.

He says he won't get a third crack at it.

Romney says his campaign didn't do a good job connecting with minority voters, and that Republicans must do a better job in appealing to African-Americans and Hispanics.

He says his campaign underestimated the appeal of Obama's new health care law to low-income voters.

But he knows that because he lost the race, it's hard to tell the GOP to listen now to what he has to say about how to improve the party's message.

The Romneys are living in Southern California now and he's kept a low profile since the election. He says "you move on" from the disappointment and that "I don't spend my life looking back."

Ann Romney says that after the election she was approached by TV's "Dancing with the Stars," but declined to join the cast.

She says she'll be turning 64 soon and "I'm not really as flexible as I should be."

The interview was taped Thursday and aired Sunday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-03-Romney/id-2d6edf57f23b414c9e925172382ed1b8

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